|WikiProject Medicine||(Rated Start-class, Low-importance)|
submitted by copyright holder. Ian Pitchford 18:32, 14 Apr 2005 (UTC)
- "En grupp svenska och engelska forskare har tillsammans studerat en liten befolkningsgrupp i Överkalix i Norrbotten och funnit ärftlig påverkan som följt med i generationer. Det handlar om yttre händelser som satt sina spår långt djupare än man hittills trott vara möjligt."
-- Petri Krohn 12:21, 27 April 2006 (UTC)
fetal origins of adult disease
Any other supporting data?
Besides human epidemiology studies, I know there have been some mouse models of this phenomenon. Anyone know the studies?
Why are people obsessing about Barker Hypothesis this much? It is a hypothesis after all. We need a cohort study or well planned transgenerational studies to test this hypothesis and this will not come easy. Such studies are very expensive and rarely conducted. Anyway emerging publications are rendering this hypothesis suspect. I plan to cite these articles mainly from JAMA. —Preceding unsigned comment added by Ayalu Reda (talk • contribs) 11:28, 23 February 2008 (UTC)
Birth weight and DMII
http://jama.ama-assn.org/cgi/content/abstract/300/24/2886 JFW | T@lk 21:32, 23 December 2008 (UTC)
The DOHaD hypothesis
The Developmental Origins of Health and Adult Disease (DOHaD) hypothesis which stems from the Barker hypothesis and Fetal origins of disease hypothesis, is a valid area of research and hence should have a page about it. The Barker hypothesis has in fact been around in some form since the late 1980's, originally it was developed through epidemiological studies which showed a significant association between adult disease (e.g. heart disease, diabetes) and low birth weight and low weight at 1 year. These results have since been replicated in many different populations, and the hypothesis expanded to include 'critical' programming periods and several further diseases. Animal studies on: sheep, mice, rats, and possible other species have been able to show a cause and effect relationship between 'insults' (e.g. low oxygen, poor nutrition, bilateral uterine vessel ligation) and adult disease. This further supports this hypothesis.
So, I think a DOHaD page should be written, containing within it FOAD. Barker's hypothesis may also be contained within this page, or left separate and expanded. —Preceding unsigned comment added by Mazzle young (talk • contribs) 13:07, 7 September 2009 (UTC)